The emerging role of orbital angular momentum (OAM) and quantum-entangled photons in tissue optics is explored in this chapter. Structured light carrying OAM demonstrates resilience to scattering and enables high-dimensional information encoding, offering new avenues for imaging, diagnosis, and treatment monitoring in biological tissues. Quantum imaging techniques leveraging spatial and polarization entanglement allow quantum-level precision and correlation measurements, uncovering subtle tissue structures and dynamics for early disease detection. Although still in early stages, these approaches show transformative potential, paving the way for next-generation biophotonic tools that transcend classical optical limits and may address critical challenges in biomedical imaging and healthcare.