The study compiles selected findings from the ongoing research conducted by the authors on the industrialisation of construction in Italy during the latter half of the 20th century. Particular attention is given to the theme of serial production and the interactions between construction and industrial design, as seen in certain structural components of buildings. The research focuses on developments in Southern Italy during the 1960s and 1970s, which reflect a know-how rooted in the North of the country, particularly in the Milan area, and an interdisciplinary collaboration among designers, architects, and engineers. The industrialisation of Southern Italy was financed by the public institution Cassa del Mezzogiorno, which catalysed the establishment of factories conceived as large-scale design objects. These were often produced by companies such as Sogene or designed by renowned figures like Marco Zanuso, commissioned by prominent clients. This study examines in greater detail the cases of Ceramica Pozzi Ginori in Sparanise and the Siemens factory in Santa Maria Capua Vetere, as well as the Olivetti project in Marcianise, designed by Marco Zanuso and Eduardo Vittoria. The article aims to shed light on the favourable contextual conditions that led to the selection of the province of Caserta as the geographical area of interest, as well as the substantial differences between the case studies analysed. These examples illustrate how structural design principles emerged as a unifying theme across these industrial projects.