Digitalization and AI technologies are reshaping the world and the way we live in it. This process, described by Floridi as the fourth revolution in human self-understanding, signifies that we are increasingly viewing ourselves as “information organisms” that are “mutually connected and embedded in an informational environment (the infosphere), which we share with other informational agents, both natural and artificial, that also process information logically and autonomously”. Developments in computer science and ICTs construct infospheres of information processing and transfer, which are shared by humans and other information artifacts. But how can interconnected information artifacts take part in intersubjective practices? To develop a discussion of this question, this chapter focuses on how digitization processes and semantic technologies offer available resources and environments for both humans and machines. After clarifying why data models and information structures can be used to represent knowledge, it will elaborate on how the internet and semantic technologies have provided a shared knowledge base across domains for networked applications and users. The practice of semantic technologies enhances the interaction and integration of cyberspace and actual space, providing new possibilities for the action and interaction of the information processing agents in it, whether natural or artificial.