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Human herpesvirus-8 (HHV-8), known as the causative agent of Kaposi’s sarcoma and other malignancies, is globally prevalent and primarily transmitted through saliva, sexual contact, and blood transfusions. This study aimed to assess the seroprevalence of HHV-8 and identify associated risk factors among blood donors. A cross-sectional study was conducted at the blood bank department of King Hussein Medical Center (KHMC), where a total of 175 blood samples were collected from healthy donors in September 2024. Serum samples were analyzed for HHV-8 IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Of the samples tested, anti-HHV-8 IgG was found in 12 (6.9%), indicating a significantly higher rate of negativity at 93.2% (P < 0.001). All positive results were observed in males, with Amman exhibiting the highest positivity rate at 4.00%. Furthermore, no significant associations were found between anti-HHV-8 seropositivity and the donors’ lifestyle or medical history. Overall, the seroprevalence of HHV-8 among Jordanian blood donors is low, with no significant correlation to lifestyle or medical history. Future studies with larger sample sizes are recommended to further explore transmission routes and risk factors, thereby improving public health and transfusion safety.

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Seroprevalence of Human Herpesvirus-8 Among Blood Donors in Jordana

  • 章节

  • 发表日期：

    2026年

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  • Rabaa Y. Athamneh,
  • Haneen AlHajia,
  • Nazih Kh. Abualsheikh,
  • Muna Barakat,
  • Aroub Kh. Albasheir,
  • Ala’a B. Al-Tammemi

摘要

Human herpesvirus-8 (HHV-8), known as the causative agent of Kaposi’s sarcoma and other malignancies, is globally prevalent and primarily transmitted through saliva, sexual contact, and blood transfusions. This study aimed to assess the seroprevalence of HHV-8 and identify associated risk factors among blood donors. A cross-sectional study was conducted at the blood bank department of King Hussein Medical Center (KHMC), where a total of 175 blood samples were collected from healthy donors in September 2024. Serum samples were analyzed for HHV-8 IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Of the samples tested, anti-HHV-8 IgG was found in 12 (6.9%), indicating a significantly higher rate of negativity at 93.2% (P < 0.001). All positive results were observed in males, with Amman exhibiting the highest positivity rate at 4.00%. Furthermore, no significant associations were found between anti-HHV-8 seropositivity and the donors’ lifestyle or medical history. Overall, the seroprevalence of HHV-8 among Jordanian blood donors is low, with no significant correlation to lifestyle or medical history. Future studies with larger sample sizes are recommended to further explore transmission routes and risk factors, thereby improving public health and transfusion safety.