This chapter lays the theoretical and methodological groundwork for a feminist disability analysis of endometriosis, a chronic gynecological condition that has long been dismissed, pathologized, and misunderstood by medicine. Drawing from feminist disability studies, rhetorical theory, medical humanities, literary criticism, and autotheory, the chapter positions endometriosis not only as a biomedical disorder, but as a cultural, political, and discursive site of power. It critiques the historic and ongoing medical neglect of femme-coded pain and reframes chronic illness as a space of epistemic resistance and feminist knowledge production. Interdisciplinary in scope, the chapter weaves archival inquiry with autotheoretical reflection, showing how personal experience becomes method and how storytelling challenges dominant frameworks of objectivity and clinical detachment. The chapter outlines the book’s structure and purpose, presenting endometriosis as a lens through which to interrogate reproductive injustice, gendered suffering, and the limitations of the medical and social models of disability studies. Through a critical engagement with disability theory and cultural representations of pain, this chapter opens a conversation about the politics of legibility, the need for disability studies to address disabilities that are purely negative in nature, and the radical possibilities of feminist rage. By centering lived experience and challenging dominant logics of normalcy, this chapter calls for a reimagining of what it means to live with, and speak from, pain.