The use of artificial intelligence (AI) in dermatology has been evolving in several aspects, including diagnosis, surveillance, treatment, and research. The associated legal and ethical implications are significant and multifaceted. The use of AI raises several essential concerns, such as accuracy and reliability, accountability and liability, informed consent, bias and equity, privacy and data security, physician–patient relationship, accessibility, transparency and explainability, autonomy, and the role of human clinicians, and regulation and oversight. Thus, it is essential to strike a balance between innovation and safety, ensuring that these technologies are deployed responsibly, do not cause harm to patients and protect patient safety, privacy, and well-being while their use in dermatology remains both effective and equitable.