This chapter provides an in-depth exploration of the aesthetic applications of botulinum toxin and dermal fillers, with a particular focus on the transformative role of artificial intelligence (AI) in enhancing procedural precision, patient safety, and individualized treatment planning. It begins with a comprehensive review of botulinum toxin, covering formulation-specific properties, dosing strategies, and anatomical considerations essential for optimal outcomes. Emphasis is placed on the importance of detailed patient assessment, with treatments tailored to individual anatomical structures and dynamic muscle behavior. In parallel, the integration of AI into aesthetic practice is transforming clinical workflows—AI-powered augmented reality (AR) platforms now enable real-time, patient-specific mapping of facial anatomy, guiding accurate injection placement and reducing complications such as asymmetry and eyelid ptosis. Furthermore, machine learning algorithms are being developed to predict immunogenic responses to botulinum toxin formulations based on dosage, frequency, and product type, improving long-term efficacy and minimizing resistance. The chapter then turns to dermal fillers, discussing their classifications, mechanisms of action, and region-specific applications. Detailed guidance is offered on injection techniques, anatomical safety zones, and complication management, including the use of hyaluronidase in cases of vascular occlusion. AI is also playing a transformative role in filler planning, with innovations such as 3D facial volumetric analysis, deep learning-based wrinkle classification, and predictive modeling of injection parameters enhancing both clinical outcomes and training. By combining anatomical expertise with AI-integrated technologies—including real-time vascular mapping and patient-specific imaging—this chapter illustrates how the field is moving toward a new era of safer, more personalized, and highly effective aesthetic care.