The MOONRISE project represents a major advancement in applying Model-Based Engineering (MBE) to industrial architecture within Airbus Defense and Space. Grounded in systems engineering and digital transformation principles, it transitions from document-based to model-centric methodologies to address the complexity and customization of modern aerospace manufacturing. This paper describes the application of MOONRISE to Airbus Defense and Space operational activities, highlighting the effectiveness of MBE approaches to enable instant design decisions, enhance integration across the different disciplines, and maximize domain-specific expertise applications. This project advanced concepts such as model lifecycle management, simulation integration, and learning curve analysis through the creation of a sophisticated and reusable digital twin of a customized unmanned aerial system. The article outlines the methodology, tools, and organizational structure used to translate theoretical concepts into practical solutions, overcoming the challenges faced by the defense industry with low production volumes and deep customization. The MOONRISE project also provides substantial empirical evidence that substantiates the role of Model-Based Engineering in ensuring digital continuity, fostering organizational cultural change, and delivering incremental benefits to business processes. The insights gained from the project advance scientific understanding and inform future business practices, making it a seminal reference case for MBE in complex industrial environments.