This chapter provides a practical guide to a range of oral conditions that, while often lacking overt lesions, significantly impact patients’ quality of life. It addresses the diagnosis and management of conditions, including dry mouth (xerostomia and hyposalivation), burning mouth syndrome (BMS), oral malodour, and taste disorders, offering insights into their aetiology, clinical presentation, and therapeutic strategies. The chapter also covers neuralgias, facial palsy, oral soft tissue lesions arising from head and neck cancer therapy, and the periodontal manifestations of diabetes. Emphasis is placed on a symptom-based approach, interdisciplinary collaboration, and patient-centred care, equipping clinicians with essential knowledge for effective management of these challenging oral conditions.