The article is devoted to the study of the influence of the combined effect of salt solutions and alternating freezing and thawing on sand-lime concrete, depending on the type and initial concentration of solutions. The necessity for research is due to the fact that the sand-lime brick masonry is exposed to de-icing agents, which are sodium chloride or calcium chloride. The studies were carried out on cylinder samples with a diameter of 3 cm and a height of 3 ± 0.1 cm. The concentration of salt solutions was 5% and 20%. Temperature and humidity conditions: freezing in air at minus 20 ± 2 ℃, thawing in water or salt solution at a temperature of plus 20 ± 2 ℃. The control parameters were: the presence of defects in appearance and compressive strength. To assess the contribution of the freezing-thawing process to the rate of destruction of sand-lime concrete, the effect of salt solutions of the same concentration on cylinder samples during moistening and drying was evaluated. It has been found that when exposed to salt solutions, the process of destruction of sand-lime concrete after freezing and thawing accelerates at a salt concentration of 5%, especially when exposed to calcium chloride, and slows down significantly at a concentration of −20%. This is explained by the fact that at a solution concentration of 5% during the cooling process, salt crystallohydrates are formed, which have a significantly larger volume than their anhydrous forms, and when cryophase is formed, the salt solution is extruded into deeper layers of concrete and, under the influence of hydraulic pressure, fills even the smallest accessible pores. At a high concentration of salt solution, ice formation does not occur due to a decrease in the freezing temperature of the liquid phase. When sand-lime concrete is exposed to alternating moistening and drying in sodium and calcium chlorides, the opposite effect is observed, the destructive processes develop faster the higher the concentration of the salt solution. Therefore, the durability of sand-lime concretes when exposed to de-icing agents under actual operating conditions must be considered in the context of alternating periods of moistening-drying and freezing-thawing.