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Molecular imaging enables both spatial and temporal understanding of the complex biological systems underlying carcinogenesis and malignant spread. Single photon emission computed tomography (SPECT) is a versatile nuclear imaging technique with ideal properties to study these processes in vivo in small animal models, as well as to identify potential drug candidates, characterize their anti-tumor action, and potential adverse effects. Small-animal SPECT, SPECT-CT (combined with computed tomography), and SPECT-MR (combined with magnetic resonance imaging) systems continue to evolve, as do the numerous radiopharmaceuticals that can be imaged by SPECT, allowing unprecedented sensitivity and quantitative molecular imaging capabilities. Several of these advances, their specific applications in oncology as well as new areas of exploration are highlighted in this chapter.

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Pre-clinical SPECT and SPECT-CT in Oncology

  • 章节

  • 发表日期：

    2026年

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  • Youngho Seo,
  • Elena M. Zannoni

摘要

Molecular imaging enables both spatial and temporal understanding of the complex biological systems underlying carcinogenesis and malignant spread. Single photon emission computed tomography (SPECT) is a versatile nuclear imaging technique with ideal properties to study these processes in vivo in small animal models, as well as to identify potential drug candidates, characterize their anti-tumor action, and potential adverse effects. Small-animal SPECT, SPECT-CT (combined with computed tomography), and SPECT-MR (combined with magnetic resonance imaging) systems continue to evolve, as do the numerous radiopharmaceuticals that can be imaged by SPECT, allowing unprecedented sensitivity and quantitative molecular imaging capabilities. Several of these advances, their specific applications in oncology as well as new areas of exploration are highlighted in this chapter.