The contribution of the University of Padua within the ASSIST project of the Italian 2022 PRIN PNRR program is focused on the design and development of prototype exoskeletons together with a smart interface for patients and doctors. The activity spans from conceptual solutions to the construction of prototype demonstrators, which have been tested to assess feasibility and operational performance. Particular attention has been devoted to creating an intuitive smartphone application for patients, complemented by a cloud-based web platform for doctors, enabling remote monitoring and supervision of therapy. The results highlight both the functionality of the hardware prototypes and the effectiveness of the integrated smart interface in supporting rehabilitation applications.