We examine the association between infrastructure development in Sub-Saharan African countries and climate change-induced vulnerability. We approach our analysis through a panel data regression framework using data from several international sources. Our regression models control for population size, economic growth, and human development and control for both country and year fixed effects. We find a positive relation between improving infrastructure development scores and vulnerability, which suggests less climate considerations in infrastructure development progress in Sub-Saharan Africa. We also find that governance factors are good for climate adaptation readiness, and that population growth worsens climate vulnerability. Human development is found to help lower climate vulnerability and has a positive association with climate adaptive capacity and readiness. We recommend that Sub-Saharan Africa countries incorporate climate resilience in their new infrastructure development agenda and invest in human development while enhancing governance mechanisms as part of the actions to sustain development that is resilient to the climate change challenges.