This chapter explores the concept and meaning effects of “self” on the field of Psychology, focusing on the semiotic making of research. Arguing against the underlying linearity in some approaches dubbed “developmental”, the author offers an alternate epistemological approach. Scaffolded by the notions of “hospitality” (the willingness to foster tension and engage with divergence as a learning opportunity) and fugue (the experimental estrangement from one’s usual self), the aim of epistemic renewal can only be reached by the twofold movement of associating with alterity and dissociating from identity, thus pioneering pathways for new knowledge.