This chapter presents a theoretical framework that conceptualizes the Self as a semiotic immune system functioning analogously to biological immunity. Drawing from Valsiner’s Dynamic Semiosis and Marsico’s Theory of Borders, this research explores how the Self maintains psychological integrity through recognition, regulation, and semiotic memory processes that distinguish between semiotic antigens, pathogens, and immunogens. The investigation employs immunological metaphors to examine how individuals process cultural meanings that challenge their established identity structures, operating through semiotic T-lymphocytes and antibodies as defensive mechanisms. Unlike traditional approaches that separate biological and cultural explanations, this work proposes a bio-semiotic integration where meaning-making is recognized as fundamentally embodied. The research demonstrates how Identity functions as a relational map—a dynamic social interface that translates internal semiotic immune processes into socially recognizable forms through co-constructive feedback loops. The framework addresses systemic failures including semiotic autoimmune conditions, where the Self mistakenly attacks its own components. Moving beyond analytical tools, this work proposes semiotic immunity as a Dynamic Ontology of the Self—redefining personhood as an ongoing immunological process of meaning negotiation. This contributes to understanding psychological resilience, identity formation, and cultural adaptation while offering an epistemological renewal that transcends nature-culture dichotomies in cultural psychology.