This chapter develops a framework that delineates the complex interplay between decision-making algorithms and the pursuit of leading a meaningful life. Initially, it defines decision-making algorithms and their integration into diverse technological devices, a crucial step in contextualizing their operational scope and potential influence on everyday decision-making. The chapter then transitions to a philosophical exploration of ‘meaning in life’, integrating insights from philosophers to establish an ethical foundation for the framework. Building upon this, the chapter critically assesses the ethical ramifications of algorithmic decision-making. It introduces a five-parameter model to encapsulate meaningfulness, comprising (1) the experience of meaningfulness, (2) autonomy, (3) skill development and self-improvement, (4) achievement in meaningful endeavors, and (5) the connection to something beyond oneself. The chapter culminates by synthesizing these insights, highlighting potential limitations and posing critical questions, thereby summarizing the chapter but also paving the way for further research in this evolving domain.