Conflict zonesConflict zones present severe challenges to mental healthMental health and sustainable development. This study proposes a theoretical frameworkTheoretical framework utilizing biophilic designBiophilic design (integrating nature into built environments) as a low-cost strategy to address these interconnected challenges. Despite increasing evidence of nature’s restorative effects in stable environments, there is a significant gap in how biophilic principles apply in high-stress, resource-limited conflict zonesConflict zones. The framework, grounded in the biophilia hypothesis, attention restoration theory (ART), and stress reduction theory (SRT), outlines physical, virtual, and socio-cultural interventions adaptable to conflict settings. The methodology employed a mixed-methods approach, combining a needs assessment survey (n = 53) in OmdurmanOmdurman, Sudan, followed by an eight-week real indoor plant intervention case study with office workers (n = 8). Data collection utilized standardized psychological measures (PSS, STAI) and physiological measurements (blood pressure), with pre-post comparative analysis to evaluate intervention effectiveness. Results from the needs assessment confirmed high levels of conflict-related stress, trauma (72% experienced displacement trauma), and limited nature access, yet a strong perceived need for nature connection. The intervention case study revealed significant improvements in employee well-being across multiple dimensions. Overall, biophilic interventions demonstrated substantial positive effects on participants’ mental healthMental health and workplace functioning, with significant reductions in physiological stress markers and psychological distress measures. This study concludes that biophilic designBiophilic design offers a practical, sustainable approach for enhancing well-being in conflict-affected populations. We recommend implementing context-specific biophilic interventions as complementary strategies in humanitarian response and post-conflict reconstruction efforts, with particular attention to cultural relevance, security considerations, and community engagement to maximize effectiveness and sustainabilitySustainability.