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This study investigated the eco-toxicological impacts of co-exposure to polyvinyl alcohol (PVA) microplasticsMicroplastics and amitriptylineAmitriptyline on C. vulgaris. AmitriptylineAmitriptyline exposure at 12 mg/L inhibited algal growth by 72.7% after 8 days, chlorophyll b content decreased by 97.3%, and the Fv/Fm value reduced to 0.22 ± 0.07. PVA mitigated AmitriptylineAmitriptyline toxicity to C. vulgaris, In C. vulgaris exposed to AmitriptylineAmitriptyline and PVA co-exposure reduced growth inhibition (36.7–26.8%), elevated chlorophyll a by 17.8%, and enhanced Fv/Fm by 17.2%. The results also showed PVA alleviated oxidative stress of AmitriptylineAmitriptyline to C. vulgaris, Compared to AmitriptylineAmitriptyline single exposure, PVA significantly reduced the malondialdehyde (MDA) content in C. vulgaris cells, the activities of superoxide dismutase and catalase increased by 7.8% and 30% respectively. The research results have deepened the understanding of the impact of microplasticsMicroplastics on the ecological toxicity of antidepressant drugs, offering insights for microalgae-based remediation of co-contaminated waters.

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Mechanistic Analysis of PVA Microplastics Mitigating Amitriptyline Toxicity to Chlorella vulgaris

  • 会议论文

  • 发表日期：

    2026年

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  • Wenjie Yuan,
  • Yelin Zhou,
  • Bingjun Shu,
  • Yicheng Wu

摘要

This study investigated the eco-toxicological impacts of co-exposure to polyvinyl alcohol (PVA) microplasticsMicroplastics and amitriptylineAmitriptyline on C. vulgaris. AmitriptylineAmitriptyline exposure at 12 mg/L inhibited algal growth by 72.7% after 8 days, chlorophyll b content decreased by 97.3%, and the Fv/Fm value reduced to 0.22 ± 0.07. PVA mitigated AmitriptylineAmitriptyline toxicity to C. vulgaris, In C. vulgaris exposed to AmitriptylineAmitriptyline and PVA co-exposure reduced growth inhibition (36.7–26.8%), elevated chlorophyll a by 17.8%, and enhanced Fv/Fm by 17.2%. The results also showed PVA alleviated oxidative stress of AmitriptylineAmitriptyline to C. vulgaris, Compared to AmitriptylineAmitriptyline single exposure, PVA significantly reduced the malondialdehyde (MDA) content in C. vulgaris cells, the activities of superoxide dismutase and catalase increased by 7.8% and 30% respectively. The research results have deepened the understanding of the impact of microplasticsMicroplastics on the ecological toxicity of antidepressant drugs, offering insights for microalgae-based remediation of co-contaminated waters.