Long-Term Effects of COVID-19 in GBD 2021
摘要
Post-COVID-19 Neurological Syndrome (PCNS) is a major but under-recognized consequence of the COVID-19 pandemic. Although many recover from acute infection, millions worldwide experience persistent neurological symptoms such as fatigue, cognitive impairment, dizziness, mood changes, and headaches. These are not merely residual complaints but represent a distinct neurological syndrome with significant clinical and societal impact. This chapter synthesizes evidence from the Global Burden of Disease study, clinical observations, patient testimonies, and policy reports to argue for PCNS as an officially recognized condition. We estimate that more than 150 million individuals are affected globally, predominantly working-age adults, with disproportionate effects in low- and middle-income countries where healthcare resources are limited. Beyond disability, PCNS contributes to loss of employment, reduced productivity, and widening social inequities. Patient narratives liken PCNS to a brain injury marked by brain fog, sensory hypersensitivity, and dysautonomia yet the syndrome remains poorly classified in international health systems such as ICD-11. Recognizing PCNS as a neurological disorder is critical for improving diagnosis, surveillance, and policy response. Doing so will also catalyze investment in research, specialized clinics, and care models tailored to patient needs. This chapter makes the case for urgent action: establishing diagnostic criteria, integrating PCNS into public health frameworks, and developing evidence-based rehabilitation strategies. Without recognition and intervention, PCNS risks becoming a long-term driver of disability and health inequity worldwide. Acknowledging PCNS as a standalone neurological condition is the first step toward meaningful solutions.