The article materials consider the methods of reducing dynamic loads that occur when overhead cranes braking with a cam-driven pad brake. The research is aimed at the development and substantiation of a new constructive solution for the brake system, which includes a ball transmission mechanism. This work scientific novelty consists in proposing a design for a brake mechanism with a variable gear ratio, which increases when the moving elements displaced after its actuation. The research carried out included the analysis of existing brake drives designs, the development of a kinematic diagram for a ball transmission mechanism, and the braking torque calculation taking into account changes in dynamic characteristics. To verify the proposed method, numerical methods based on an overhead crane three-mass dynamic model have been used. Calculations confirm that the use of a cam drive with a ball transmission mechanism reduces dynamic loads in the machine’s drive and metal structure by 20–25%, while maintaining braking efficiency. This study of practical value lies in increasing the durability and reliability of overhead cranes’ brake systems due to the uniform distribution of braking force and reduction of peak dynamic loads. The results obtained can be used in the design of new braking devices and modernization of existing systems.