The dynamic development of modern technologies, coupled with the e-commerce boom intensified by the COVID-19 pandemic, has led to significant changes in consumer behaviour, characterized by an unprecedented scale of online shopping. However, this trend poses challenges for urban logistics, particularly in the area of last-mile deliveries, which are considered the most expensive and least efficient segment of the supply chain. In response to these issues, the implementation of innovative logistics solutions, such as parcel lockers (PLs, APMs), is crucial. This article focuses on the concept of agnostic (open) parcel locker networks, which, unlike closed systems, enable the shared use of infrastructure by multiple logistics operators. The aim of the study is to analyse the potential of open (agnostic) parcel locker networks in optimising last-mile logistics in the context of the dynamic growth of the e-commerce market. Based on a targeted literature review, including selected case studies (Bergen, Korneuburg, Kaumberg, Singapore), key economic, environmental, and social conditions accompanying the implementation of open parcel locker infrastructures were identified. The results indicate that agnostic models can reduce courier route lengths, contribute to the reduction of CO2 emissions, and increase service availability in peripheral areas. At the same time, the findings emphasise that successful implementation of agnostic networks requires a high degree of stakeholder coordination, as well as clearly defined regulatory frameworks and strategic location planning.