Scholarlink

This article presents the development and experimental testing of a perfusion module for the extracorporeal anti-ischemic protection of a donor heart using an automatic control system. The research addresses a key problem in transplantology: the limited viability of donor organs during traditional preservation. The module is based on a closed hydraulic circuit with peristaltic pumps, a temperature-controlled chamber, and sensors. Computer modeling in MATLAB/Simulink optimized the design by analyzing fluid flow balance and system stability. Experimental effectiveness was confirmed on isolated rat hearts. Hypothermic (+8 ℃) perfusion with an oxygenated HTK solution was maintained for 12 h at 0.3 ml/min and 10 cm H₂O pressure, compared to a control group using static hypothermia (+4 ℃). The results demonstrated that the module successfully restored sinus rhythm (268–325 beats/min) and contractile function (left ventricular pressure up to 82 mmHg) after reperfusion. This study confirms the module's efficacy for the long-term preservation of donor heart viability. The combination of engineering solutions (modeling, automated control) and medical technology offers promising prospects for optimizing dynamic organ preservation methods.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development of a Perfusion Module with Automatic Parameter Maintenance in Feedback Mode

  • 会议论文

  • 发表日期：

    2026年

查看全文
  • P. A. Ermolaev,
  • T. P. Khramykh,
  • A. A. Kuznetsov,
  • I. R. Barkhatov

摘要

This article presents the development and experimental testing of a perfusion module for the extracorporeal anti-ischemic protection of a donor heart using an automatic control system. The research addresses a key problem in transplantology: the limited viability of donor organs during traditional preservation. The module is based on a closed hydraulic circuit with peristaltic pumps, a temperature-controlled chamber, and sensors. Computer modeling in MATLAB/Simulink optimized the design by analyzing fluid flow balance and system stability. Experimental effectiveness was confirmed on isolated rat hearts. Hypothermic (+8 ℃) perfusion with an oxygenated HTK solution was maintained for 12 h at 0.3 ml/min and 10 cm H₂O pressure, compared to a control group using static hypothermia (+4 ℃). The results demonstrated that the module successfully restored sinus rhythm (268–325 beats/min) and contractile function (left ventricular pressure up to 82 mmHg) after reperfusion. This study confirms the module's efficacy for the long-term preservation of donor heart viability. The combination of engineering solutions (modeling, automated control) and medical technology offers promising prospects for optimizing dynamic organ preservation methods.