The phenomenon of brain death, characterized by its sudden onset and complex nature, is frequently misunderstood. In the context of Hong Kong, eligibility for organ donation is restricted to individuals who have succumbed to brain death. Consequently, families of the deceased are confronted with the decision to consent to organ donation, a process that imposes significant emotional burdens as they navigate their grief and face a constrained timeframe for decision-making. Organ donation coordinators (ODCs) are specialized advanced practice nurses who facilitate organ donation services. Their crucial function in promoting efficient and secure organ transplants involves maintaining effective communication with frontline healthcare professionals and orchestrating the multidisciplinary organ procurement process. Furthermore, ODCs provide steadfast support, acute grief counseling, and compassionate guidance to bereaved families. They assist in elucidating the concept of brain death and address any concerns by actively addressing potential misconceptions or conflicting beliefs while delivering accurate information. ODCs strive to empower families to make informed decisions based on a comprehensive understanding of organ donation, ultimately ensuring that their choices are respected and honored. This chapter examines the intricacies of brain death, organ donation, and the emotional repercussions faced by grieving families in Hong Kong. It also presents real-world experiences from ODCs, detailing their approach to managing common emotional responses and supporting families throughout the arduous journey of grief and decision-making.