Preliminary electrolysis experiments provided evidence of phono-fission reactions occurring in condensed matter (see Chap. 10 ). These experiments were characterized by significant neutron and alpha particle emissions, together with appreciable variations in the chemical composition on the electrode surfaces. A macromechanical reason for the so-called “Cold Nuclear Fusion” is proposed. The hydrogen embrittlement due to hydrogen atoms produced by the electrolysis plays an essential role in the production of microcracking in the electrode host metals (Ni–Fe and Co–Cr alloys). Our hypothesis is that phono-fission reactions occur in correspondence to the microcrack formation and/or propagation. In order to confirm the early results obtained by the Ni–Fe and Co–Cr electrodes and presented in the previous chapter, electrolytic tests are conducted using 100% Pd at the cathode and 90% Ni at the anode. As a result, relevant chemical composition changes and the appearance of elements previously absent are observed on the Pd and Ni electrodes after the experiment, as well as significant neutron and alpha particle emissions. The most relevant process emerging from the experiment is the primary fission of palladium into iron and calcium. Then, secondary fissions of the products, as well as of nickel on the other electrode, in turn appear producing oxygen atoms, as well as additional alpha particles and neutrons.