Building-integrated photovoltaic (BIPV) systems are a promising solution for the transition to zero energy buildings (ZEB), enabling power generation directly from the building envelope. However, in some configurations, increasing the operating temperature of PV modules can lead to a significant reduction in their efficiency. Ventilated façades with integrated PV modules emerge as an effective strategy to mitigate this problem, utilising cavity ventilation to maintain lower operating temperatures and improve overall system performance. This paper focuses on the analysis of a real building located in Switzerland, characterised by ten facades entirely clad with PV modules. Through the two-dimensional fluid-dynamic modelling of a section of one of these facades, the thermo-fluid dynamic behaviour of the system was studied. Thanks to a monitoring system installed on site, it was possible to obtain precise data on the boundary conditions—ambient temperature, solar irradiation and wind speed—and to validate the accuracy of the simulation results. Comparisons between simulated and measured PV module temperatures showed encouraging results, suggesting the potential of this simulation approach for analysing and optimizing the performance of PV ventilated façades. Further refinement of the simulation process is underway to enhance the accuracy of the results.