Textile-Reinforced Mortar (TRM) has proven to be an effective strengthening solution for masonry-infilled reinforced concrete (RC) frames. Recent studies attempted to integrate TRM strengthening with standard thermal insulation, with promising results. However, the so-far solutions make use of ordinary portland cement-based binders (OPC), the production of which is a major contributor to global CO2 emissions. More sustainable mortars, such as those containing alkali-activated materials (e.g. geopolymers), can help address this issue, as recent studies have shown that they can offer similar or better performance than standard OPC mortars. This study aims to investigate the combination of structural and energy retrofitting of existing masonry-infilled RC frames. One-story, one-bay specimens were constructed at a 1:2.5 scale. Regarding the strengthened specimen, basalt fiber meshes embedded in metakaolin-based geopolymer mortar were used for structural retrofitting, while a conventional thermal insulation system with expanded polystyrene was used for energy retrofitting. The two specimens were subjected to in-plane cyclic loading.