Headache disorders are prevalent and disabling conditions. Capturing the burden of headaches requires a comprehensive and consistent methodology that enables comparison across territories, conditions, age groups and sex. The Global Burden of Disease (GBD) study relies on Disability-Adjusted Life Years (DALYs) to track burden and on Years Lived with a Disability (YLDs) to track health loss due to a condition. In this chapter, a comprehensive analysis of health loss due to all headaches, migraine and tension-type headache (TTH) is presented. TTH is one of the most prevalent conditions, and migraine is among the leading causes of YLDs. The amount of health loss, as described by YLDs, associated with headache disorders corresponds to correspond to 67.5% of that associated with neurological conditions, and to 5.3% of all-cause YLDs. Among the most exposed group, i.e., women aged 15–49, headaches account for 8.3% of all-cause YLDs. The estimates presented herein basically show that gender and age differences with regard to the health loss associated with headache disorders are not significant. Similarly, differences by location, SDI, and period (2000–2010–2021) are not significant. In sum, headaches are prevalent and disabling conditions, and their impact is quite homogeneous across locations, sexes, and periods. This homogeneity is due to the overdispersion of YLDs, which is common in conditions with limited hospitalization, but it is also likely to reflect the unequal access to care. Actions need to be taken to reduce the burden of headache disorders: in particular, it is imperative to understand the main risk factors for headache so as to be able to plan adequate policies and interventions.