As AI technology extends through all areas, some say that we are entering an AI-driven world, one with a deterministic worldview and with no need for understanding why and how we choose/believe the way we do. Accordingly, it is a fact that AI disruption has advanced throughout our individual lives, the economy, and various professions, including medicine. As this deterministic world expands, it integrates AI into medical decision-making, affecting the autonomy of both physicians and patients. Epistemic and ethical implications can also be identified, particularly, concerning of AI’s influence on the physician-patient relationship. As AI recommendations pressure patients and physicians, tension emerges between AI-driven recommendations and the physician’s convincing powers. This chapter aims to explore the disruptive nature of AI in terms of the dynamics and trustworthiness typical of a physician-patient relationship. To this aim, Emanuel and Emanuel’s traditional four mainstream models of that relationship have been scrutinized, and the question of which model would best suit our times explored. Given the complexity of this relationship, coupled with AI, a new model, the Philosophically Pluralistic Model, inspired in Feyerabend’s philosophy, is finally outlined to better address the ethical, scientific, and epistemic issues surrounding the disruption of AI in the physician-patient relationship.