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Iron is an essential mineral for cardiopulmonary health, playing a crucial role in oxygen transport and cellular metabolism. Iron homeostasis is a complex process, with derangements in iron metabolism playing a role in the pathophysiology of numerous diseases. We explore the clinical impact of dysregulated iron homeostasis, detailing the pathophysiology of both iron deficiency and iron overload. The discussion focuses on the roles of these states in significant cardiopulmonary disorders, including heart failure, pulmonary hypertension, and iron overload cardiomyopathy. Finally, we summarize the evidence from major clinical trials evaluating iron replacement therapies and discuss the therapeutic implications for managing these complex conditions.

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Functional Biochemistry of Iron and Its Cardiopulmonary Impact

  • 章节

  • 发表日期：

    2026年

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  • Keshav Garg,
  • Nitesh Gautam,
  • Prachi Saluja,
  • Allison Shaw Devine,
  • Jawahar L. Mehta

摘要

Iron is an essential mineral for cardiopulmonary health, playing a crucial role in oxygen transport and cellular metabolism. Iron homeostasis is a complex process, with derangements in iron metabolism playing a role in the pathophysiology of numerous diseases. We explore the clinical impact of dysregulated iron homeostasis, detailing the pathophysiology of both iron deficiency and iron overload. The discussion focuses on the roles of these states in significant cardiopulmonary disorders, including heart failure, pulmonary hypertension, and iron overload cardiomyopathy. Finally, we summarize the evidence from major clinical trials evaluating iron replacement therapies and discuss the therapeutic implications for managing these complex conditions.