Scholarlink

Breast cancer has emerged as a significant global health concern in recent years, making the prevention of this disease dependent on various chemotherapeutic and alternative therapy options. Micronutrients, including vitamins and minerals and plant-derived bioactive components, play a crucial role in the body through gene expression, cellular growth, and immunomodulation. It is well known that certain micronutrients, such as vitamins A, B, C, D, and E, coenzyme Q10, omega-3 fatty acids, and minerals like Se, Zn, Fe, Mg, and Cu, serve multifunctional roles in cancer development or suppression, depending on their systemic concentration and bioavailability. Some micronutrients may act as inhibitors, while others could function as potential tumor promoters due to their roles in gene regulation and cellular signaling transduction. Micronutrients can regulate key cancer signaling pathways, including the PI3K-AKT, MAPK, and JAK-STAT pathways, thereby controlling cell proliferation, apoptosis, and immune function. Hence, interventions with micronutrients are potential therapeutic options for the management of breast cancer. The significance of micronutrient therapy in breast cancer prevention also arises from their epigenetic control of gene expression. This chapter provides a comprehensive understanding of the efficacy of micronutrient-based interventions for preventing breast cancer.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Role of Micronutrients in Managing Breast Cancer: Implications of Supplementation Therapies on Molecular and Cellular Signaling Pathways

  • 章节

  • 发表日期：

    2026年

查看全文
  • Mandeep Singh Sibian,
  • Mini Chaturvedi,
  • Imtiyaz Alam Khan,
  • Payal Sharma,
  • Vivek Kumar Garg,
  • Harpal S. Buttar,
  • Vaishali Aggarwal

摘要

Breast cancer has emerged as a significant global health concern in recent years, making the prevention of this disease dependent on various chemotherapeutic and alternative therapy options. Micronutrients, including vitamins and minerals and plant-derived bioactive components, play a crucial role in the body through gene expression, cellular growth, and immunomodulation. It is well known that certain micronutrients, such as vitamins A, B, C, D, and E, coenzyme Q10, omega-3 fatty acids, and minerals like Se, Zn, Fe, Mg, and Cu, serve multifunctional roles in cancer development or suppression, depending on their systemic concentration and bioavailability. Some micronutrients may act as inhibitors, while others could function as potential tumor promoters due to their roles in gene regulation and cellular signaling transduction. Micronutrients can regulate key cancer signaling pathways, including the PI3K-AKT, MAPK, and JAK-STAT pathways, thereby controlling cell proliferation, apoptosis, and immune function. Hence, interventions with micronutrients are potential therapeutic options for the management of breast cancer. The significance of micronutrient therapy in breast cancer prevention also arises from their epigenetic control of gene expression. This chapter provides a comprehensive understanding of the efficacy of micronutrient-based interventions for preventing breast cancer.