Micronutrients, vitamins, and minerals are very important and essential in the development and healthy growth of the human body, as well as in healthy living in general. In the main biochemical reactions and basic metabolism, micronutrients play a central and significant role in the balance of these functions. All vitamins and minerals are required molecules as the structural components of various cells and biochemical processes so they are important for healthy development and balance of organism. Most of the risk factors for micronutrient deficiency are still not clearly known. According to the WHO, deficiency of micronutrients is defined as a low concentration of vitamin/mineral in tissue, enough to have adverse effects on health. Some of the risk factors for deficiency could be attributed to characteristics of micronutrient, age, gender, ethnicity and religious variability, comorbidity, lifestyle, and drug or food consumption. In very small amounts, all micronutrients are essential for normal health and well-being, such as chlorine, manganese, iron, copper, molybdenum, zinc, selenium, etc. The term mineral toxicity means that the levels of soluble micronutrients exceed a tolerance threshold. Assessment of the safety of micronutrients from food or as a supplement is undertaken by identifying the adverse effects produced by higher intake, which is consequence of the dose-depended effects of micronutrients. Micronutrient toxicities are less common than deficiencies, and they are more often due to higher intake of lipo-soluble vitamins such as vitamin A, D, E, and K because of their ability to be stored in organism fat tissue and liver. On the other hand, deficiency of the hydro-soluble vitamin is more common than toxicities because of the fast excretion though the renal system.