Surgical treatment for complete rotator cuff (RC) tears is recommended when conservative therapy fails or when the patient has a high risk of tear progression. All-arthroscopic repair techniques are the gold standard for treating small-to-medium full-thickness RC lesions. In fact, these methods yield good clinical results and a high rate of patient satisfaction in both short- and long-term follow-up, with no clinical differences among the various surgical configurations (single-row, double-row, suture bridge, and arthroscopic transosseous repair). However, the retear rate of RC tendons is still high; therefore, new biological therapies are emerging to promote tendon healing.