Anterior cruciate ligament (ACL) injuries are common, and controversy remains regarding optimal graft selection for reconstruction. Using allograft for ACL reconstruction has numerous advantages, including decreased operative time, lack of donor-site morbidity, and small surgical incisions. Several drawbacks, including the risk of bloodborne disease transmission, higher reported failure rates in younger patient populations, and compromised graft structural integrity secondary to sterilization and processing, potentially limit its utility. The goal of this chapter is to review the various allograft options available for ACL reconstruction, the influence of allograft sterilization and processing on graft biomechanics, and the recent literature comparing the use of allograft versus autograft.