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Atherosclerosis, the pathobiological basis for cardiovascular disease, begins in childhood and its presence and severity is directly linked with the presence of cardiovascular risk factors (CVRFs), including modifiable factors such as hypertension, dyslipidemia, and obesity. The impact of these CVRFs can be assessed using subclinical assessments of target organ damage and atherosclerosis burden through tests such as pulse wave velocity, flow-mediated dilation, left ventricular mass, and carotid intima media thickness. This chapter will outline the relationship between CVRFs in childhood with subclinical measurements of target organ damage and atherosclerosis in adulthood. The early detection and management of CVRFs from childhood may in turn reduce subclinical and manifest cardiovascular disease in adulthood.

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Childhood CV Risk Factors Predicting Adult Subclinical Target Organ Injury

  • 章节

  • 发表日期：

    2026年

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  • Bushra Anjum,
  • Michael Khoury

摘要

Atherosclerosis, the pathobiological basis for cardiovascular disease, begins in childhood and its presence and severity is directly linked with the presence of cardiovascular risk factors (CVRFs), including modifiable factors such as hypertension, dyslipidemia, and obesity. The impact of these CVRFs can be assessed using subclinical assessments of target organ damage and atherosclerosis burden through tests such as pulse wave velocity, flow-mediated dilation, left ventricular mass, and carotid intima media thickness. This chapter will outline the relationship between CVRFs in childhood with subclinical measurements of target organ damage and atherosclerosis in adulthood. The early detection and management of CVRFs from childhood may in turn reduce subclinical and manifest cardiovascular disease in adulthood.