In Kantian ethics, the autonomy of the will and the use of practical reason constitute the grounds for morality. Moral imperatives are “a priori” principles. They include the principle of universalizability (first formulation), the principle of humanity (second formulation), and the autonomy of the will (third formulation). There are three important limitations for applying Kantian ethics in a business context: profit maximization could allow organizational executives and directors to curb the principle of humanity; imperfect duties (such as the duty of beneficence and the duty to protect the environment) could be occasionally fulfilled; ethical leadership and culture could hardly be developed, since the flexibility required to prevent and resolve ethical dilemmas and conflicts is too demanding. The antecedents of a crisis of moral principles (the will to power, the degeneration of corporate transparency and honesty) must be taken seriously, when addressing the probability to face such crisis in the future. At the onset of the crisis, those antecedents could play a decisive role in organizational members’ ethical positioning. Developing ethical leadership, revising governance mechanisms and structures, and deepening the system of meanings related to the organizational culture are optimal solutions to a crisis of moral principles.