Pulmonary hypertension (PH) is a condition characterized by a gradual increase in pulmonary artery (PA) pressure, leading to eventual right ventricular (RV) failure. The diagnostic challenges associated with PH stem from the nonspecific nature of its symptoms, often leading to delayed identification. The performance and adaptability of the RV, influenced by the intricate interplay between the PA and RV as a morphofunctional unit, have a profound impact on patients’ outcomes. This chapter provides an overview of the pathophysiology of PH, emphasizing the practical aspects of quantitative imaging parameters that can be evaluated in echocardiography, computed tomography, cardiac magnetic resonance, and radionuclide scans. By employing these quantitative measures, imaging can play a crucial role in facilitating early detection, accurate diagnosis, and ongoing monitoring of PH.