Consciousness and Reason are generated and controlled by the genetic code. Appealing to the genome when creating strong artificial intelligence (AI) is inevitable. The spiral structure of DNA contains part of the genetic information and is a source of a long-range electromagnetic field and radiation. The genome can be considered as a sequential oscillatory circuit with distributed parameters. Genome-based AI (GAI) is a quasi-stationary substance that includes some forms of the genome and its environment, independently establishing its states due to its own internal fields and signals. Various forms of DNA, a minimal part of the code, neurocode, electromagnetic copy, etc. can be used as an agent. Known physical effects are applicable for activation, training, self-development, feeding of GBAI and setting tasks: fields and radiation with various types of modulations. The result of the GAI work is the states of self-organization of the highest levels of the genome. Physically, this is a stable oscillating interference of waves of various vibrations and code emissions, structural patterns. A translator will be needed between a person and the GAI. It is necessary to take into account the features the features of the GAI: uncertainty and unpredictability, scale invariance, the presence of inner vision, sexual duality, internal self-checking, etc. The signal extracted from the genome has an independent practical value. Genome-based AI is a quasi-stationary substance that includes some forms of the genome and its environment, independently establishing its states due to its own internal fields and signals. Technological readiness for the creation of GAI is gradually growing out of known border areas: genetics, neurotechnology, biotechnology. The application of physical principles to the study of the genetic code and the phenomenon of consciousness has great potential.