Mulberry (Morus spp.) is an economically important perennial crop mainly cultivated for its succulent foliage. Silkworm, Bombyx mori L. feeds solely on mulberry foliage and leaf quality determines the growth and development of silkworm larvae. Hence, production of nutritious mulberry leaves determine the silk quality. Nutritional quality of mulberry leaves is mainly depends on primary metabolites such as protein, amino acids, carbohydrates, vitamins (ascorbic acids and tocopherols) etc. and leaf moisture percentage. Yield and quality of mulberry leaves may significantly influenced by various climatic factors such as rainfall, temperature, relative humidity and soil parameters. Climate change will negatively affects the plant growth and development by altering the morpho-physiological attributes in plants due to the cumulative impact of various biotic and abiotic stresses. Among abiotic stresses drought, flood/waterlogging, soil salinity and alkalinity are the major threats to mulberry cultivation. Climate change results in the significant rise in temperature and atmospheric CO2, which will affects yield and physiological efficiency of the plants. Higher CO2 concentration affects the synthesis and translocation of metabolites in plants. Physiological anomalies may cause reduction in quality leaf harvest. Genotypes with higher physiological and water use efficiency (WUE) traits (root biomass and root length, epicuticular wax, photosynthetic rate, stomatal conductance, chlorophyll, water potential, relative water content, etc.) could be identified and utilized for crop improvement. Identification of morpho-physiological adaptive traits and development of climate resilient varieties through trait oriented breeding approaches is the most appropriate strategy for climate resilient crop production.