Mulberry (Morus spp. family Moraceae) tree is a perennial, heterozygous, and out breeding species. It is extensively found in temperate and subtropical parts of China, India, Uzbekistan, Brazil, Japan, North Korea, Thailand, Vietnam, Iran, and other countries that have been the primary locations of its commercial cultivation. Primarily, the crop is used to feed silkworms (Bombyx mori L.) and boost the economy of the poorest parts of society. However, it also serves secondary incomes by utilizing mulberry fruit, pharmaceutical companies, herbal tea, wine, beverages, etc. Like other crops, genomic data is crucial to comprehend the mulberry genetic resources concerned with the persistent risks created by climate change. Here we have focused specifically on available nuclear and chloroplast genome resources, and comprehended their structural and functional aspects including SSR, InDles, and SNPs. Additionally, we have tried to establish relationships between genome size, with structural variations, in turn present discussion highlighted important aspects of evolutionary consequences of species and ploidy relationships. Furthermore, we have capitalized system biology, and web tools/software that can be useful to decode the genetic architecture of mulberry for further sustainability of sericulture. Moreover, the present book chapter highlights the utilization of genomic information for future breeding, biotechnology as well as conservation of mulberry in response to climate change.