The popularity of biodegradable Mg alloys as potential metallic biomaterialsBiomaterials for vascular and orthopedic temporary implants is increasing, due to their favorable mechanical, electrochemical, and biological propertiesProperties. Nevertheless, several challenges persist with Mg scaffolds, including rapid degradation, inadequate mechanical propertiesMechanical properties, and intricate manufacturing processesProcess. Alloying and processing are pivotal methods for improving the propertiesProperties of Mg alloys for use in biomedical applications. This study focuses on the development of the process technologyProcess technology for the fabrication of ultra-precise geometries and the achievement of the mechanical and degradation propertiesProperties for biodegradable vascular stents. To this end, a two-step extrusion processProcess has been developed to manufacture microtubesMicrotube. Subsequently, machine learningMachine learning was employed to reverse-engineer Mg–Zn–Mn–Sr–Ca (ZMJX) alloys for biodegradable microtubesMicrotube with enhanced strengthStrength and reduced degradation rate. The present study investigates the room-temperatureTemperature tensile propertiesTensile properties and biodegradationBiodegradation of ZMJX alloy microtubesMicrotube in terms of extrusion ratio, microstructureMicrostructure, and texture.