This work presents a fifth-order adaptive self-modeling network model to explain the effects of environmental factors and epigenetic changes associated with the development of schizophrenia and mania. Our model focuses on how prenatal stress can cause long-term disruptions in cognitive control, disrupting working memory processes in both disorders. It is based on biological and neurological structures to represent the multi-level interactions between environmental, (epi)genetic, and cognitive factors. Two scenarios were simulated: one depicting the emergence of working memory deficits after prenatal stress, and another demonstrated recovery after a targeted therapeutic intervention by clozapine. This paper provides a framework for analyzing how gene-environmental interactions influence mental disorders over time, contributing to its etiology and progression.