Upper-limb amputations constitute a clinical condition with a profound impact on patients’ quality of life, limiting functional autonomy and social integration. Over the past decades, various types of hand prostheses have been developed to compensate for anatomical loss and to partially restore motor function. However, highly personalized prosthetic models often require considerable financial investment, which in most cases is not affordable for the affected population. In this context, the present study proposes the development of a personalized mechanical hand prosthesis fabricated through three-dimensional printing, aiming to achieve reduced cost while maintaining anatomical precision and functional reliability. The design of the prosthesis is based on the segmentation of computed tomography images, which ensures an individualized adaptation to the patient’s morphology. Subsequently, the digital models are optimized using a computer-aided design software, enabling the evaluation of structural and functional parameters as well as durability testing prior to manufacturing. This approach integrates medical image segmentation, digital modeling, and additive manufacturing to provide an accessible and scalable strategy for hand prosthesis development. It is anticipated that this workflow will contribute both to the clinical management of amputee patients and to the advancement of applied research in biomechanics and rehabilitation.