The seismic performance of unreinforced masonry (URM) buildings may be significantly affected by previous damage induced by ground settlement. Assessing the structural behaviour under these combined effects is challenging due to the cumulative nature of damage, which can strongly influence the onset, evolution, and form of collapse mechanisms. This study investigates the impact of these combined actions through an extensive experimental programme involving several 1:4-scale dry joint granite stone masonry façades with openings. The specimens were subjected to a stepped settlement, which introduced slight to severe damage in the walls, followed by tilting, that led to in-plane collapse. The paper provides a detailed description of specimens, material characterisation, testing apparatus and protocol. Finally, preliminary results are presented for the specimens featuring symmetric piers and a central opening arrangement. The primary findings indicate the consistent appearance of cracks in specific areas of the panels, although crack patterns differed across repeated tests. Greater settlement magnitudes reduced the wall’s capacity to resist tilting, and the position of the settling pier in relation to the rotation axis had a significant impact on both the collapse angle and the failure mechanism.