With crystal growing techniques having been around since the nineteenth century, lab-grown crystals now drive innovations in various industries. This has, however, not fully translated to the jewellery industry, where they continue to be the subject of great debate. This chapter explores a selection of innovations achieved with ‘Neo-gemstones®’ and the practice of urban mining in relation to the retrieval of gemstone waste to enable these sustainable and creative jewellery applications. Through a selection of examples, such as the use of off-cuts to grow in-situ rubies in metal structures, the chapter aims to showcase how these practices not only reduce environmental impact but also contribute to the aesthetic and economic value of jewellery. Whilst requiring an adapted design approach, urban mining and localised crystal growth has the potential to reshape the jewellery industry, injecting micro-political will into channels currently predominantly regulated by large international industry players.