This chapter defines design as the intentional transformation of knowledge into novel, useful artifacts and argues for a science of design that makes practice teachable, auditable, and improvable. Tracing key foundations and the emergence of Design Science as a field, it introduces the Artifacts–Actions–Actors (3A) framework as a unifying lens. We position design science as a metascience for innovation, advancing unified principles that shift innovation from episodic luck to disciplined, repeatable progress across domains and scales.