Negative pressure wound therapy (NPWT) is increasingly recognized as a cornerstone in modern wound care due to its effectiveness in managing complex wounds. This chapter provides a comprehensive, practical, step-by-step guide for healthcare professionals on the application of traditional NPWT techniques. It addresses key aspects such as indications, preparation, application, and troubleshooting, alongside best practices and contraindications crucial for optimizing wound healing and minimizing complications. By promoting granulation tissue formation and enhancing perfusion through controlled negative pressure, NPWT facilitates effective wound management. We aim to equip healthcare professionals with the necessary skills and knowledge to confidently implement traditional NPWT in clinical settings, ultimately contributing to improved patient outcomes and the overall efficacy of wound care practices.