The Sensor-S study pioneers a novel integration of multimodal wearable sensors with standard care stroke rehabilitation through a randomized controlled trial design, representing a significant advancement in post-stroke care methodology. Our technical framework combines synchronized inertial measurement units, medical-grade smartwatches, and continuous glucose monitors to objectively quantify recovery biomarkers while maintaining gold-standard clinical protocols. Initial results from 27 participants demonstrate the system’s technical robustness. Clinically, we observe improvements in movement smoothness (15–22% reduction in normalized jerk scores) and gait symmetry (18% reduction in deviation indices), while simultaneously achieving a high patient compliance with daily wearable use. The adaptive trial design allows continuous refinement of technical components (e.g., reducing IMU packet loss). As the study progresses toward full enrollment (n = 156), these interim results provide preliminary insights towards the potential of wearable systems to bridge the critical gap between objective measurement and therapeutic intervention in post-stroke recovery.