This study explored the correlation between senior high school students’ information literacy levels and their usage of Generative Artificial Intelligence (GenAI) chatbots. Additionally, it sought to determine whether there were significant differences in students’ information literacy levels when grouped according to grade level, academic track, and socio-economic class. A total of 367 senior high school students from a private secondary school in the Philippines secondary school participated in the study, with data collected through a researcher-developed survey instrument. The results revealed that senior high school students demonstrated a high level of information literacy. Notably, the Mann–Whitney U and Kruskal–Wallis tests found no significant differences in information literacy across grade level, socio-economic class, and academic track. Spearman’s correlation analysis indicated very weak and non-significant correlations between students’ information literacy levels and their usage of GenAI tools, both for supporting learning and misuse. The study emphasizes the importance for secondary schools to continue strengthening students’ information literacy skills and educate them on the responsible use of GenAI tools in learning.