Nano technology is amongst the majestic fields of the twenty-first century, which can restructure a broad-spectrum of human activities, the most notable ones being medicine, energy sector, environment reconstruction and agriculture. On the one hand, its significant generality creates an urgent need to conduct an extensive analysis of the toxicity profile, ecological consequences, and supply effective regulatory frameworks, which imposes limitations on its extensive implementation and safety in operation. Green nanotechnology as a similar equivalent to green chemistry and engineering attempts to find ways to exploit plant based systems, as well as renewable substrates, in the production of nanoparticles. Among such rearrangement, the energy industry and medicine take especially central stands. In the nano domain biosynthesis, the progress and characterization of (CuO) nanoparticles and, silver nanoparticles (AgNPs) is an extremely notable improvement in that case, since this delivers, high efficiency, harmless to the environment, a cheap, and harmless alternative to the known physical and chemical methods. Phytochemical material helps to worsen the impacts of plant extracts because they can reduce, stabilize, and capped agents which prevent glycation of any by-tropical products formed. In addition, these biogenic nanoparticles have applications beyond drug development and targeted drug delivery and include wastewater treatment, heavy metal remediation, and the enhancement of agricultural productivity. However, environmental release can cause major complications in the form of biodiversification, cytotoxicity, and ecological imbalance, all of which require severe levels of safety testing and policy development. Technologically, the material properties characterizing the use of UV-Vis spectroscopy, FTIR, SEM, TEM, XRD will enable the accurate parameters optimization to satisfy the application context requirements. The future application of nanoparticle platforms to precision medicine, smart materials, and circular economy models is also expected to further enrich therapeutic efficiencies, environmental sustainability, and efficient use of resources. The current review will summarize recent Production progress of plant-derived nanoparticles, outline their multiple uses, scrutinize potential impacts on the environment and health, outline prospective opportunities to reach the full potential of sustainable nanotechnology.