The healing of wounds is a critical aspect of medical care, and developing effective wound dressings is essential for promoting recovery and preventing infections. This chapter explores the innovative use of plant-based nanomaterials in the design of advanced wound dressings. These nanomaterials offer unique advantages, including biocompatibility, biodegradability, and antimicrobial properties by leveraging the natural properties of materials such as cellulose, chitosan, and alginate. The chapter discusses various fabrication techniques, such as electrospinning, freeze-drying, and 3D printing, to create Nano fibrous scaffolds that facilitate moisture retention and gas exchange while providing a protective barrier. Mechanisms of drug incorporation for localized delivery of antimicrobial agents and growth factors are also examined, highlighting the potential for enhanced healing outcomes. Applications in the treatment of acute and chronic wounds are addressed, along with a discussion of the challenges and future directions in the field. Overall, integrating plant-based nanomaterials into wound dressing strategies represents a promising advancement in wound care, contributing to improved patient outcomes and reduced healthcare costs.